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Daniel J. Panyard, PhD

Stanford University

U.S. Department of Veteran's Affairs

About me

I am a postdoctoral research fellow in the Snyder Laboratory, Department of Genetics, School of Medicine at Stanford University. My work focuses on applying the latest multiomics and precision health technologies to the study of complex disease. I am also a research associate with the U.S. Department of Veteran's Affairs.

I earned my PhD in Epidemiology and a Certificate in Bioinformatics at the University of Wisconsin-Madison, advised by Drs. Corinne Engelman and Qiongshi Lu. My dissertation demonstrated the feasibility of a genomics-based approach to study the relationship of scarce omics (CSF metabolomics) with health and disease. Throughout my time at UW-Madison, I worked on a wide range of epidemiological studies, including efforts to address risk factors of rheumatoid arthritis through electronic health records systems, gene expression patterns in sulfa drug allergies, tissue-based polygenic risk scores for markers of neurodegeneration, the CSF proteomics of Alzheimer's disease, and the genomics of plasma metabolite levels.

Interests

  • Molecular epidemiology
  • Multiomics
  • Precision health
  • Complex disease
  • Bioinformatics
  • Alzheimer's disease
  • Aging

Education

  • PhD in Epidemiology, 2020

    University of Wisconsin-Madison

  • Certificate in Bioinformatics at the Graduate Level, 2018

    University of Wisconsin-Madison

  • BS in Physiology, 2010

    Michigan State University

Research projects

 
 
 
 
 

Multiomic profiling of health, disease, and aging

Dr. Mike Snyder

September 2020 – Present Stanford University
Designing, analyzing, and interpreting multiomic data sets in human health and disease.
 
 
 
 
 

Metabolomics, microbiome, and Alzheimer's disease

Alzheimer's Disease Metabolomics Consortium

November 2019 – August 2020 University of Wisconsin-Madison
Cleaned, processed, and contributed both CSF and plasma metabolomics data on behalf of the Engelman Laboratory to the Alzheimer's Disease Metabolomics Consortium, an international collaboration that aims to understand the relationship between the gut microbiome and Alzheimer's disease.
 
 
 
 
 

Genomics of Plasma Metabolites

COMETS Consortium

June 2019 – August 2020 University of Wisconsin-Madison
Led the University of Wisconsin's effort to participate in the COMETS international consortium to study the relationship between genomics and plasma metabolite levels. Cleaned, processed, imputed, and analyzed genomic and plasma metabolomic data, conducting GWAS for 865 metabolites.
 
 
 
 
 

Proteomics of Alzheimer's Disease

Drs. Corinne Engelman and Joshua Coon

July 2018 – Present University of Wisconsin-Madison
Analyzed cerebrospinal fluid proteomics in Alzheimer's disease. A pilot study of CSF proteomics was conducted from 2018-2019 in a small sample to determine the optimal parameters for generating untargeted proteomics data in the context of Alzheimer's. The pilot data were used to lay the groundwork for a larger study of CSF proteomics and metabolomic in 137 individuals.
 
 
 
 
 

Integration of genomics, metabolomics, and brain-related phenotypes

Drs. Qiongshi Lu and Corinne Engelman

September 2017 – August 2020 University of Wisconsin-Madison
Dissertation work. Built cerebrospinal fluid metabolite prediction models and combined them with GWAS summary statistics to analyse the relationship between CSF metabolites and neurological and psychiatric phenotypes. Demonstrated the feasibility of this framework (MWAS) to extend our ability to study the omics of scarce sample types.
 
 
 
 
 

T32 Traineeship Rotation

Dr. Sunduz Keles

June 2017 – September 2017 University of Wisconsin-Madison
Analyzed RNA-seq and epigenomics in a murine anemia model.
 
 
 
 
 

T32 Traineeship Rotation

Dr. Sushmita Roy

January 2017 – June 2017 University of Wisconsin-Madison
Built prediction models for long-range chromatin interaction.
 
 
 
 
 

T32 Traineeship Rotation

Dr. Michael Newton

August 2016 – December 2016 University of Wisconsin-Madison
Analyzed gene expression in the context of sulfa antibiotic hypersensitivity.
 
 
 
 
 

Research/project assistant

Dr. Christie Bartels

January 2015 – January 2016 University of Wisconsin-Madison
Analyzed the impact of clinic protocols on hypertension and tobacco use among rheumatology patients.

Publications

Large-scale proteome analysis of CSF implicates altered glucose metabolism in Alzheimer's disease
Pilot proteomic analysis of cerebrospinal fluid in Alzheimer's disease

Documents

EDI statement

Approach to supporting equity, diversity, and inclusion

Teaching statement

Approach to teaching and mentoring

CV

Curriculum vitae

Contact info

Email me at dpanyard[at]stanford[dot]edu.